NAD+

Nicotinamide Adenine Dinucleotide (NAD) is a coenzyme found in every cell of your body. It plays a crucial role in energy metabolism, helping convert food into energy and supporting key biological processes like DNA repair, cell communication, and immune function. NAD exists in two forms in the body: NAD+ (oxidized) and NADH (reduced). NAD+ is involved in the processes that produce energy, while NADH carries energy within cells.

Functions of NAD+:

1. Energy Production: NAD+ is essential for converting carbohydrates, fats, and proteins into usable energy (ATP) within the mitochondria of cells.

2. DNA Repair and Maintenance: NAD+ helps repair damaged DNA, which is essential for maintaining healthy cells and tissues.

3. Cellular Repair and Aging: NAD+ activates proteins called sirtuins, which help regulate aging processes, inflammation, and cellular repair mechanisms.

4. Brain and Cognitive Health: NAD+ supports brain function by regulating neurotransmitter release and protecting against neurodegeneration.

Why is NAD+ Important?

As we age, NAD+ levels naturally decline, leading to decreased energy, slower repair processes, and potential increased vulnerability to age-related diseases like Alzheimer’s, cardiovascular diseases, and diabetes. Maintaining healthy NAD+ levels is thought to support longevity and reduce the effects of aging and chronic diseases.

Sources of NAD

1. Endogenous Production: The body produces NAD+ from the amino acid tryptophan and vitamin B3 (niacin).

2. Dietary Sources: Niacin-rich foods like turkey, chicken, fish, peanuts, mushrooms, and whole grains can support NAD+ production.

3. NAD+ Supplements: Some people take NAD+ precursors like nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) to help boost NAD+ levels, though more research is needed to understand their full impact.

NAD+ and Health Conditions

1. Aging and Longevity: NAD+ is often studied for its potential to promote healthy aging by supporting cellular repair and preventing age-related declines in health.

2. Neurodegenerative Diseases: Research suggests that increasing NAD+ levels may help protect against diseases like Alzheimer’s, Parkinson’s, and Huntington’s.

3. Cardiovascular Health: NAD+ may improve blood vessel function and protect against heart disease by regulating inflammation and energy metabolism.

4. Metabolic Disorders: NAD+ plays a role in regulating glucose and fat metabolism, making it a potential target for treating conditions like diabetes and obesity.

How to Maintain Healthy NAD+ Levels

• Regular Exercise: Physical activity has been shown to boost NAD+ levels.

• Balanced Diet: A diet rich in niacin-containing foods (e.g., turkey, salmon, and brown rice) can support NAD+ production.

• Adequate Sleep: Sleep is essential for cellular repair processes that depend on NAD+.

• Supplements: NAD+ boosters like NR and NMN are available over-the-counter, though their long-term effects and safety are still being researched.

Potential Side Effects

Though NAD+ supplementation is generally considered safe, the long-term effects are not yet fully understood. Some people may experience mild side effects like nausea, headaches, or digestive discomfort. It’s important to consult a healthcare provider before starting any supplement regimen, especially for people with preexisting health conditions or who are taking other medications.

Glutathione

Glutathione is made up of three amino acids: glutamine, cysteine, and glycine. It is often referred to as the "master antioxidant" because it helps neutralize harmful substances in the body. It is important for:

  • Detoxification

  • Immune system support

  • Protecting against oxidative stress (damage caused by free radicals)

  • Supporting liver health

  • Regulating other antioxidants in the body

    How does Glutathione work?

    • Antioxidant Action: It neutralizes free radicals and reactive oxygen species (ROS), which are unstable molecules that can damage your cells and lead to aging and diseases.

    • Detoxification: It helps the liver detoxify harmful substances, such as heavy metals, by making them easier to excrete.

    • Immune Support: Glutathione helps the immune system function effectively by maintaining healthy levels of white blood cells.

    • Regulating Other Antioxidants: It helps regenerate other antioxidants in the body, allowing them to keep fighting oxidative stress.

    • Why is Glutathione important?

      • Glutathione is essential for overall well-being and health, as it:

        • Supports liver health by aiding in the detoxification process.

        • Helps the immune system function properly, reducing the risk of infections.

        • Potential Side Effects

          • While glutathione supplementation is generally considered safe for most people, some may experience side effects such as:

            • Allergic reactions (skin rash, itching)

            • Digestive discomfort (nausea or bloating)

            • Breathing problems (if inhaled in aerosol form)

            If you’re considering glutathione supplementation, it's important to talk to your healthcare provider to determine the appropriate dose and form for your needs.

          • Before taking Glutathione.

            • Tell your healthcare team about your medical history.

            • Tell your provider if you have or have ever had kidney or pancreas disease, a history of diabetic retinopathy or any stomach problems such as difficulty digesting food.

            • Tell your provider if you become, or plan to become, pregnant, are pregnant, or are breastfeeding.